The tyrosine kinase Lyn limits the cytokine responsiveness of plasma cells to restrict their accumulation in mice

Abstract

Maintenance of an appropriate number of plasma cells, long-lived antibody-producing cells that are derived from B cells, is essential formaintaining immunological memory while limiting disease. Plasma cell survival relies on extrinsic factors, the limited availability of which determines the size of the plasma cell population. Mice deficient in the nonreceptor tyrosine kinase Lyn are prone to an autoimmune disease that is characterized by inflammation and an excess of plasma cells (plasmacytosis). Wedemonstrated that the plasmacytosis was intrinsic to B cells and independent of inflammation. We also showed that Lyn attenuated signaling by signal transducer and activator of transcription 3 (S..